First selective direct mono-arylation of piperidines using ruthenium-catalyzed C–H activation
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چکیده
منابع مشابه
First selective direct mono-arylation of piperidines using ruthenium-catalyzed C–H activation
ABSTRACT A Ru-catalyzed mono-arylation in α-position of saturated cyclic amines is reported employing a C-H activation protocol. Substitution of the pyridine directing group with a bulky group, e.g., trifluoromethyl in the 3-position, proved to be crucial to avoid bis-arylation. This highly selective transformation can be performed with different amines and arylboronate esters. Additionally, th...
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ژورنال
عنوان ژورنال: Monatshefte für Chemie - Chemical Monthly
سال: 2013
ISSN: 0026-9247,1434-4475
DOI: 10.1007/s00706-013-0947-1